SIRT1 and Kidney Function

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SIRT1 and Kidney Function.

BACKGROUND SIRT1 is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases. Abundantly expressed in the kidney, especially in the renal medulla, SIRT1 is closely involved in renal physiology and pathology. SUMMARY SIRT1 targets both histone and nonhistone proteins, participates in many important signaling pathways and mediates the regulation ...

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ژورنال

عنوان ژورنال: Kidney Diseases

سال: 2015

ISSN: 2296-9381,2296-9357

DOI: 10.1159/000440967